Aeglea BioTherapeutics To Evaluate Combination Treatment With Merck For Small Cell Lung Cancer

Aeglea BioTherapeutics To Evaluate Combination Treatment With Merck For Small Cell Lung Cancer

Aeglea BioTherapeutics (AGLE) said Monday it will collaborate with Merck (MRK) to evaluate the combination of Aeglea’s AEB1102 with Merck’s Keytruda for the treatment of patients with small cell lung cancer (SCLC). “Given the emerging relevance of checkpoint inhibitors, such as Keytruda in SCLC, this collaboration represents an exciting step forward for Aeglea as we investigate the potential of [AEB1102] to treat this devastating disease,” said Aeglea’s chief medical officer […]

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Karyopharm Therapeutics Licenses Cancer Drugs to Ono Pharmaceutical in Japan

Karyopharm Therapeutics Licenses Cancer Drugs to Ono Pharmaceutical in Japan

Karyopharm Therapeutics (KPTI) said Thursday it has reached an exclusive license agreement for the development and commercialization of the potential cancer drugs selinexor and KPT-8602 with Japan’s Ono Pharmaceutical. The agreement includes the development of selinexor and KPT-8602 for the diagnosis, treatment and/or prevention of all human oncology indications in Japan, South Korea, Taiwan, Hong Kong, and Association of Southeast Asian Nations countries. Under the terms, Karyopharm will receive a […]

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Flexion Therapeutics Prices Sale of 4.8 Mln Shares at 2.7% Discount

Flexion Therapeutics Prices Sale of 4.8 Mln Shares at 2.7% Discount

Flexion Therapeutics (FLXN) said late Wednesday it has priced an underwritten public offering of 4.8 million shares at $25.50 each or a 2.7% discount to the closing price. The company said gross proceeds are expected to be approximately $122.4 million. Flexion has granted underwriters a 30-day option to buy an additional 720,000 shares. The company said it plans to use net proceeds to fund manufacturing and commercialization of Zilretta, which […]

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Beacon Roofing Supply Prices Offering of $1.3 Bln Senior Notes

Beacon Roofing Supply Prices Offering of $1.3 Bln Senior Notes

Beacon Roofing Supply (BECN) said after market close on Wednesday that it has priced its previously announced private offering of $1.3 billion of 4.875% senior notes due 2025. The initial offering price to investors will be 100% of the principal amount thereof. The offering is expected to close on Oct. 25. The net proceeds from the offering, along with certain additional funds, will be deposited in a segregated escrow account. […]

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Bond Prices Claw Back to Little-Changed – 10-Year 2.33%

Bond Prices Claw Back to Little-Changed – 10-Year 2.33%

U.S. Treasury prices headed out little-changed but lower in muted trade with the market losing an early bid as September services sector data jumped to a much higher-than-expected 12-year high while other reports were nearly in line to a bit better. The market continued to hear chatter and react to potential replacements for Federal Reserve Chair Janet Yellen, with prices rising on the more dovish choices and falling on the […]

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